Title
Amphiphilic polypyrrole-poly(Schiff base) copolymers with poly(ethylene glycol) side chains: Synthesis, properties and applications
Date Issued
21 August 2018
Access level
open access
Resource Type
journal article
Author(s)
Molina B.G.
Cianga L.
Bendrea A.D.
Cianga I.
Estrany F.
Alemán C.
Armelin E.
Universitat Politècnica de Catalunya
Publisher(s)
Royal Society of Chemistry
Abstract
New amphiphilic poly(ethylene glycol) (PEG)-grafted random intrinsically conducting copolymers which combine three different functionalities have been engineered, prepared and characterized. Specifically, these "rod-coil" type copolymers bear conducting polypyrrole (PPy) and poly(Schiff base) (PSB) sequences randomly distributed in their backbones; hydrophilic grafted side chains consisting of well-defined PEG chains are attached to the PSB units. Basically, the synthesis of the copolymers is conducted sequentially by employing the "macromonomer" technique via electrochemical co-polymerization of a bis (pyrrole) benzoic Schiff base-containing PEG macromonomer with pyrrole monomers. After investigation of the chemical and electrochemical properties of the synthesized copolymers, their advantages of multi-functionality in terms of biomedical applications have been demonstrated. More specifically, the conjugated PPy and PSB sequences enabled the grafted copolymers to exhibit great ability to catalyse the oxidation of serotonin, an important neurotransmitter found in blood platelets and in the central nervous systems of animals and humans. On the other hand, the enhanced biocompatibility in comparison with bare PPy is due to the presence of PEG side chains, while bacteriostatic activity against both Gram-negative and Gram-positive bacteria is imparted by the synergistic combination of the polycationic character of the PPy main chain with the benzoic Schiff base functional groups and with the bent-shaped architecture of the facially amphiphilic PSB sequences, respectively. Accordingly, these grafted copolymers are promising materials for developing implantable electrodes for serotonin detection which present the abovementioned characteristics.
Start page
4218
End page
4232
Volume
9
Issue
31
Language
English
OCDE Knowledge area
Ingeniería química Electroquímica
Scopus EID
2-s2.0-85051244733
Source
Polymer Chemistry
ISSN of the container
17599954
Sponsor(s)
This work was supported by MINECO (MAT2015-69367-R) and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2017SGR359). Support for the research by C. A. was received through the prize “ICREA Academia 2015” for excellence in research, funded by the Generalitat de Catalunya (Catalonia-Spain). B. G. M. is thankful to CONACYT agency for their financial support through a postgraduate scholarship (328467 CVU 621314). The authors are grateful to Prof. G. Lisa from the Faculty of Chemical Engineering and Environmental Protection of “Gheorghe Asachi” Technical University, Iasi, Romania for TGA and DSC measurements. The Romanian authors dedicate this paper to Professor Bogdan C. Simionescu on the occasion of his 70th birthday.
Sources of information: Directorio de Producción Científica Scopus