Title
15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics
Date Issued
01 August 2015
Access level
open access
Resource Type
review
Author(s)
Conde J.
Ambrosone A.
Tian F.
McCully M.
Berry C.C.
Baptista P.V.
Tortiglione C.
De La Fuente J.M.
University of Zaragoza
Publisher(s)
Elsevier B.V.
Abstract
Summary RNAi has always captivated scientists due to its tremendous power to modulate the phenotype of living organisms. This natural and powerful biological mechanism can now be harnessed to downregulate specific gene expression in diseased cells, opening up endless opportunities. Since most of the conventional siRNA delivery methods are limited by a narrow therapeutic index and significant side and off-target effects, we are now in the dawn of a new age in gene therapy driven by nanotechnology vehicles for RNAi therapeutics. Here, we outlook the "do's and dont's" of the inorganic RNAi nanomaterials developed in the last 15 years and the different strategies employed are compared and scrutinized, offering important suggestions for the next 15.
Start page
421
End page
450
Volume
10
Issue
4
Language
English
OCDE Knowledge area
Nano-materiales
Biotecnología relacionada con la salud
Subjects
Scopus EID
2-s2.0-84946604791
Source
Nano Today
ISSN of the container
17480132
Sponsor(s)
This work has been funded by ERANET-NANOSCIERA NANOTRUCK project. JC acknowledges Marie Curie International Outgoing Fellowship (FP7-PEOPLE-2013-IOF, project no. 626386). JMF acknowledges SAF2014-54763-C2-2-R project (Spanish Government), European Regional and Social Development Funds , Aragón Autonomous Government (DGA) through Research Groups and ERC-Starting Grant 239931-NANOPUZZLE .
Dr. Jesus M. de la Fuente (Barakaldo, 1975) started his PhD work in 1999 on the evaluation of carbohydrate-carbohydrate interactions using gold nanoparticles (IIQ-CSIC, Seville, Spain). Once he obtained his PhD, he was funded by the Spanish Science Ministry to work in the Centre for Cell Engineering at The University of Glasgow (UK) to develop a research project involving the biological application of nanoparticles. In June 2007, he gained a permanent position in the Institute of Nanoscience of Aragón (INA) belonging to the University of Zaragoza (Spain) as Senior Researcher supported by ARAID. He currently leads the research group specialized in the Biofunctionalization of Nanoparticles and Surfaces. His research interests are based on the development of general and simple strategies for the functionalization of nanoparticles and surfaces for biomedical and biotechnological applications. He has 100 published articles with more than 2800 citations and 5 international patents. From 2014 he is a visiting Professor at the Shanghai Jiao Tong University (P.R. China) under the “1000 People Plan Program”.
Sources of information:
Directorio de Producción Científica
Scopus