Title
[1-8-NαlC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum
Date Issued
27 May 2016
Access level
metadata only access
Resource Type
journal article
Author(s)
Dos Beirigo P.
Torquato H.
Dos Santos C.
De Carvalho M.
Castro R.
De Sousa P.
Jacinto M.
Da Silva V.
Universidade Federal de São Paulo
Publisher(s)
American Chemical Society
Abstract
A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).
Start page
1454
End page
1458
Volume
79
Issue
5
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Scopus EID
2-s2.0-84971656724
PubMed ID
Source
Journal of Natural Products
ISSN of the container
01633864
Sources of information:
Directorio de Producción Científica
Scopus