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Publication1, 2, 4-Triazole as a reference material for combustion calorimetry of N-containing compounds( 2001-01-01)
;Roux M. ;Torres L.A micro-bomb combustion calorimeter recently designed for samples of mass ≈80 mg has been improved and tested with m-methoxybenzoic acid in order to verify the chemistry of the combustion process and the accuracy of the energy corrections involved in the analysis of results. From measurements in this calorimeter, the standard massic energy of combustion of 1, 2, 4-triazole was determined to be Δcuo = -(19200.3 ± 3.4) J·g−1. Some new measurements with our macro combustion calorimeter confirm an earlier result from this laboratory of -(19203.1 ± 1.2) J·g−1. Determination of the purity by d.s.c. of 1, 2, 4-triazole purified some 10 years ago reveals that samples of this compound remained unchanged and suggest that 1, 2, 4-triazole be used as a possible reference material for organic compounds with a high content of nitrogen. From the experimental results with the micro-bomb combustion calorimeter, the actual and earlier results from macro-bomb combustion calorimetry, and those obtained in other laboratories, the standard massic energy of combustion of 1, 2, 4-triazole was deduced to be Δcuo = -(19202.5 ± 1.7) J·g−1. © 2000 Academic Press. -
Publication1,3-Diethyl-2-thiobarbituric acid as an alternative coinitiator for acidic photopolymerizable dental materials(Wiley-Blackwell, 2013-10-01)
;Münchow E. ;Valente L. ;Fernández M. ;Lima G. ;Petzhold C. ;Piva E.Ogliari F.The ethyl-4-dimethylaminobenzoate (EDAB) is widely used as a coinitiator of the camphorquinone (CQ), but in acidic circumstances it might present some instability, reducing the polymerization efficiency of the material. Considering this, new coinitiators are being evaluated. Hence, this study evaluated the kinetic of polymerization (KP), the degree of conversion (DC), and the rate of polymerization (RP) of experimental resin adhesives containing 1,3-diethyl-2-thiobarbituric acid (TBA) as a coinitiator of the CQ. The experimental monomeric blend was prepared with bisphenol A glycidyl dimethacrylate, 2-hydroxyethyl methacrylate, and acidic monomers. CQ was added at 1 mol % as photoinitiator. Six groups were formulated: four containing concentrations of 0.1, 0.5, 1, and 2 mol % of TBA, one without coinitiator, and the last one containing 1 mol % of EDAB (control group). The KP and the R P were performed using real-time Fourier Transform infrared spectroscopy. The group without coinitiator has not formed a polymer, whereas the addition of TBA resulted in the conversion of monomers in polymer. The DC of the adhesives was as higher as the increase in the TBA content. The group with 2 mol % of TBA presented improved DC and reactivity (RP) than the other groups and the control one. Hence, the TBA has performed as a coinitiator of the CQ for the radical polymerization of methacrylate resin adhesives and it has improved the DC and the reactivity of the materials. Thus, it is a potential coinitiator for the photopolymerization of dental materials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1217-1221, 2013. Copyright © 2013 Wiley Periodicals, Inc., a Wiley Company. -
Publication[1-8-NαlC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum(American Chemical Society, 2016-05-27)
;Dos Beirigo P. ;Torquato H. ;Dos Santos C. ;De Carvalho M. ;Castro R. ;De Sousa P. ;Jacinto M.Da Silva V.A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM). -
Publication10 years evaluation of the diagnostic and therapeutic value of the lithium transport ratio in bipolar disorder: preliminary report(Elsevier, 1993-01-01)
;Poletti L.Cazorla A. -
Publication10-Year experience on renal cell carcinoma at the instituto de enfermedades neoplasicas(Wiley-Blackwell, 1997-12-01)
;Pow-Sang M.OBJECTIVE. Renal cell carcinoma (RCC) was first described in 1826. We analyse retrospectively 58 pts who underwent radical nephrectomy and determine their survival MATERIALS: Between Januray 1974 and December 1985, 58 pts with RCC underwent radical nephrectomy (nephrectomy and lymphadenectomy). The series comprised 40 males and 18 females (ratio 2.2:1), with a mean age of 66 years (r 13-85). RESULTS: Mean time of symptoms prior to treatment was 1 to 6 months 16 pts (27,5%), and more than 6 monts 42 pts (71,8%). Robson classification of the tumor showed 12 pts stage I (20,7%), 1 stage II (1,7%), 6 stage III (10,3%) and 31 stage IV (53,5%); in 8 pts (13,8%) stage unknown since these pts had surgery in other hospital.Tumor grade was weel differentiated in 21 pts (36,2%), moderatelly differentiated in 20 (34,5%), and poorly differentiated in 4 (6,9%); tumor grade was unknown in 13 (22,4%). Six pts (6,4%) had tumors between 5-1 Ocm, and 33 pts (57%) tumors more than 10cm; in 19 pts (32,7%) tumor size was unknown. There were 5 post-op deathts (8,6%). Five-year survival for stage I was 50% and 41,7% at 10 years. In this group, 2 pts died because of distal metastatic disease at 12 and 16 years, respectively. The only pt in stage II survived for 9 years, at which time developed lung metastasis, dying from the disease. Two-year survival for stage III was 50%, then all pts lost to follow-up. For stage IV, all pts (31/31 - 100%) died within 3 years from surgery. CONCLUSIONS: Our survival is similar to that described in the literaure, as well as surgical mortality. RCC, in their initial stages, will rescue 50% of pts at 5 years, and 41,7% at 10 years. -
Publication10.2 Zymosan and specific-rickettsia activation of oxygen free-radicals production in Pecten maximus hemocytes( 1989-01-01)
;Le Gall G. ;Bachere E.Grizel H. -
Publication10.3 Chemiluminescent responses of Ostrea edulis and Crassostrea gigas hemocytes to Bonamia ostreae (Ascetospora)( 1989-01-01)
;Hervio D. ;Bachere E.Grizel H. -
Publication100-nm thick single-phase wurtzite BAlN films with boron contents over 10%(Wiley-VCH Verlag, 2017-08-01)
;Li X. ;Wang S. ;Liu H. ;Detchprohm T.Dupuis R.D.Growing thicker BAlN films while maintaining single-phase wurtzite structure and boron content over 10% has been challenging. In this study, we report on the growth of 100 nm-thick single-phase wurtzite BAlN films with boron contents up to 14.4% by MOCVD. Flow-modulated epitaxy was employed to increase diffusion length of group-III atoms and reduce parasitic reactions between the metalorganics and NH3. A large growth efficiency of ∼2000 μm mol−1 was achieved as a result. Small B/III ratios up to 17% in conjunction with high temperatures up to 1010 °C were utilized to prevent formation of the cubic phase and maintain wurtzite structure. -
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Publication[11]Isolation of candidate genes for inherited diseases: Application to X-linked retinal degenerations( 1996-01-01)
;Yan D.Swaroop A. -
Publication12 novel clonal groups of leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka(Public Library of Science, 2021-03-01)
;Jayasundara D. ;Senavirathna I. ;Warnasekara J. ;Gamage C. ;Siribaddana S. ;Kularatne S.A.M. ;Matthias M. ;Mariet J.F. ;Picardeau M. ;Agampodi S.Leptospirosis is a ubiquitous zoonotic disease and a major clinical challenge owing to the multitude of clinical presentations and manifestations that are possibly attributable to the diversity of Leptospira, the understanding of which is key to study the epidemiology of this emerging global disease threat. Sri Lanka is a hotspot for leptospirosis with high levels of endemicity as well as annual epidemics. We carried out a prospective study of Leptospira diversity in Sri Lanka, covering the full range of climatic zones, geography, and clinical severity. Samples were collected for leptospiral culture from 1,192 patients from 15 of 25 districts in Sri Lanka over two and half years. Twenty-five isolates belonging to four pathogenic Leptospira species were identified: L. interrogans, L. borgpetersenii, L. weilii, and L. kirschneri. At least six serogroups were identified among the isolates: Autumnalis (6), Pyrogenes (4), Icterohaemorrhagiae (2), Celledoni (1), Grippotyphosa (2) and Bataviae (1). Seven isolates did not agglutinate using available antisera panels, suggesting new serogroups. Isolates were sequenced using an Illumina platform. These data add 25 new core genome sequence types and were clustered in 15 clonal groups, including 12 new clonal groups. L. borgpetersenii was found only in the dry zone and L. weilii only in the wet zone. Acute kidney injury and cardiovascular involvement were seen only with L. interrogans infections. Thrombocytopenia and liver impairment were seen in both L. interrogans and L. borgpetersenii infections. The inadequate sensitivity of culture isolation to identify infecting Leptospira species underscores the need for culture-independent typing methods for Leptospira. -
Publication12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells: Regulation by extracellular signal-regulated protein kinases and glutathione( 2004-01-30)
;Ramos A.M. ;Sancho P. ;Amrán D. ;De Blas E.Aller P.Arsenic trioxide (As2O3) caused apoptosis in U-937 human promonocytic cells. This effect was potentiated by the simultaneous addition of the glutathione (GSH) synthesis inhibitor DL-buthionine-(R,S)-sulfoximine or the protein kinase C activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and bryostatin 1. In addition TPA decreased the intracellular GSH content, caused ERK activation, and potentiated the As2O3-provoked activation of p38 and JNK. The addition of N-acetyl-L-cysteine, the PKC inhibitor GF109203X, and the MEK/ERK inhibitors PD98059 and U0126 attenuated both apoptosis induction and GSH decrease, whereas the p38 inhibitor SB203580 and the JNK inhibitor SP600125 were ineffective. TPA also potentiated ERK activation and GSH depletion when added simultaneously to cadmium chloride (CdCl2) and doxorubicin. However, TPA only enhanced apoptosis in the case of CdCl2, which is a GSH-sensitive agent, whereas it reduced the toxicity of doxorubicin and other DNA-specific drugs. Finally, preincubation for 14-24 h with TPA did not potentiate but, instead, attenuated the As2O3- and CdCl2-provoked apoptosis. The same result was obtained by preincubation with bryostatin 1 and other differentiation inducers. It is concluded that TPA increases the apoptotic action of As2O 3, an effect mediated by ERK activation and GSH depletion. However, the increase in apoptosis is only effective in non-differentiated cells. -
Publication(127–135) Proposals to add new Provisions and Recommendations to Division III of the International Code of Nomenclature for algae, fungi, and plants related to virtual participation in the Nomenclature Section: Special-purpose Committee on Virtual Participation in the Nomenclature Section(International Association for Plant Taxonomy, 2021-12-01)
;Landrum L.R. ;Fortunato R. ;Barkworth M. ;Breitwieser I. ;Demissew S. ;Dönmez A.A. ;Dutta S. ;Freire-Fierro A. ;Kim Y.D. ;Moore G. ;Mosyakin S.L. ;Oh S.H. ;Parra-O C. ;Prado J. ;Arce L.R. ;Sennikov A.N.Smith G.F. -
Publication129 Effect of equine chorionic gonadotrophin doses on number and size of ovarian follicles at the time of oocyte collection in llamas(NLM (Medline), 2021-12-01)
;Perez U.H. ;Gutierrez F.W. ;Quispe Y.M. ;Melgar J.H. ;Luque N. ;Palomino J.M. -
Publication13C NMR metabolomics: INADEQUATE network analysis(American Chemical Society, 2015-06-02)
;Clendinen C. ;Ajredini R.Edison A.The many advantages of 13C NMR are often overshadowed by its intrinsically low sensitivity. Given that carbon makes up the backbone of most biologically relevant molecules, 13C NMR offers a straightforward measurement of these compounds. Two-dimensional 13C-13C correlation experiments like INADEQUATE (incredible natural abundance double quantum transfer experiment) are ideal for the structural elucidation of natural products and have great but untapped potential for metabolomics analysis. We demonstrate a new and semiautomated approach called INETA (INADEQUATE network analysis) for the untargeted analysis of INADEQUATE data sets using an in silico INADEQUATE database. We demonstrate this approach using isotopically labeled Caenorhabditis elegans mixtures. -
Publication14C AMS dating of fires in the central Amazon rain forest(Elsevier, 2000-01-01)
;Santos G. ;Gomes P. ;Anjos R. ;Cordeiro R. ;Di Tada M. ;Cresswell R.Fifield L.Soil samples were collected in tierra firme upland and lowland areas of the Km 41 reserve near Manaus (20°30′S and 60°W), in Central Brazilian Amazon, within a 1700 m transect, at eight different depth ranges, from surface to 100 cm. The highest charcoal concentrations were found at the depth range of 20-50 cm. AMS radiocarbon dating of 31 samples were performed at the ANU. The ages of the charcoals were found to vary within the 130 to 2400 years BP range, mostly between 1200 and 1400 years BP, one of the known Holocene dry periods of the Amazon region. The results show that the fires have regional dimensions and are associated with climate regional changes. © 2000 Elsevier Science B.V. All rights reserved. -
Publication14C edimentary chronology and carbon cycle: Implications for paleoclimatic change in Brazil( 2008-09-26)
;Simões F.F.L.A 14C chronological study from sediments in lacustrine environments in Brazil was developed to assess climate and environmental changes during the Holocene. In the middle of the great debate concerning late glacial in Amazonia, the Holocene period has been somewhat forgotten. The Amazonian climate during Holocene was probably drier and certainly more variable than the present-day one. Global Circulation Models (GCM) applied to 6000 BP pointed out that lower summer insolation was the reason of lower precipitations at that time. © 2008 American Institute of Physics. -
Publication14C-AMS as a tool for the investigation of mercury deposition at a remote Amazon location( 2004-08-01)
;Barbosa J.A. ;Cordeiro R.C. ;Silva E.V. ;Gomes P.R.S. ;Santos G.M. ;Sifedinne A. ;Albuquerque A.L.S. ;Lacerda L.D. ;Hausladen P.A. ;Tims S.G. ;Levchenko V.A.Fifield L.K.We present results of the atmospheric mercury deposition rate in the Amazon region during the last 43000 years. Lake sediment samples were collected from the Lagoa da Pata, a small and remote lake in northern Brazilian Amazon. The samples were divided in sub-samples, for C, Hg, N and 14C-AMS analyses. Three main paleoclimatic events could be identified. The mercury accumulation rates were found to be larger during the periods of the Holocene and Pleistocene associated with high temperatures and frequency of forest fires. © 2004 Elsevier B.V. All rights reserved. -
Publication15 Years of Software Regression Testing Techniques - A Survey(World Scientific Publishing Co. Pte Ltd, 2016-06-01)
;Rosero R. ;Gómez O.Software regression testing techniques verify previous functionalities each time software modifications occur or new characteristics are added. With the aim of gaining a better understanding of this subject, in this work we present a survey of software regression testing techniques applied in the last 15 years; taking into account its application domain, kind of metrics they use, its application strategies and the phase of the software development process where they are applied. From an outcome of 460 papers, a set of 25 papers describing the use of 31 software testing regression techniques were identified. Results of this survey suggest that at the time of applying a regression testing techniques, metrics like cost and fault detection efficiency are the most relevant. Most of the techniques were assessed with instrumented programs (experimental cases) under academic settings. Conversely, we observe a minimum set of software regression techniques applied in industrial settings, mainly, under corrective and maintenance approaches. Finally, we observe a trend using some regression techniques under agile approaches. -
Publication15 years on siRNA delivery: Beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics(Elsevier B.V., 2015-08-01)
;Conde J. ;Ambrosone A. ;Tian F. ;McCully M. ;Berry C.C. ;Baptista P.V. ;Tortiglione C.De La Fuente J.M.Summary RNAi has always captivated scientists due to its tremendous power to modulate the phenotype of living organisms. This natural and powerful biological mechanism can now be harnessed to downregulate specific gene expression in diseased cells, opening up endless opportunities. Since most of the conventional siRNA delivery methods are limited by a narrow therapeutic index and significant side and off-target effects, we are now in the dawn of a new age in gene therapy driven by nanotechnology vehicles for RNAi therapeutics. Here, we outlook the "do's and dont's" of the inorganic RNAi nanomaterials developed in the last 15 years and the different strategies employed are compared and scrutinized, offering important suggestions for the next 15.